Complete Surgical Guide

Total Ankle Replacement

By Dr. Sagar Desai, MD, MSc, FRCSC
Orthopaedic Surgeon, Foot and Ankle Reconstruction
Toronto, Ontario, Canada

Everything patients ask Dr. Sagar Desai about ankle arthritis and total ankle replacement — causes, fusion vs. replacement, the procedure itself, and recovery — organized below by topic.


Chapter 1

Understanding Ankle Arthritis

By Dr. Sagar Desai, MD, MSc, FRCSC
Orthopaedic Surgeon, Foot and Ankle Reconstruction
Toronto, Ontario, Canada

The ankle joint is covered with a smooth layer of cartilage that lets the bones glide almost frictionlessly against one another while walking. Ankle arthritis develops when this cartilage gradually wears away from either side of the joint — the tibia and the talus. Once the protective layer is lost, bone begins rubbing directly on bone, causing pain, swelling, stiffness, and a progressive loss of motion. As it worsens, even walking short distances or standing for long periods can become extremely uncomfortable.

Unlike arthritis of the hip or knee, the majority of ankle arthritis is post-traumatic — it develops after an injury. Many patients are surprised that an injury from 10, 20, or even 30 years ago presents as arthritis later in life: the ankle may have seemed to heal well, but cartilage damaged during the original injury slowly progresses until painful arthritis develops.

Previous ankle fractures

The ankle may initially heal well, but cartilage damaged during the injury can progress to arthritis.

Ligament injuries

A common cause of post-traumatic ankle arthritis.

Repetitive ankle sprains

One of the injuries most patients with ankle arthritis have experienced.

Cartilage injuries

An injury from 10, 20, or even 30 years ago can present as arthritis later in life.

Diagnosis begins with a discussion of symptoms and previous injuries and an examination of motion, swelling, alignment, and tenderness. Weight-bearing X-rays are the most important test; a CT scan adds detail when surgery is being considered, while MRI is rarely helpful for standard ankle arthritis.

Thankfully, most patients don’t need surgery right away. Dr. Desai recommends exhausting non-operative treatment first whenever possible — activity modification, supportive footwear, custom orthotics, bracing, physiotherapy, anti-inflammatory medication, and injections. When these no longer provide adequate relief and ankle pain starts interfering with everyday life, surgery may become the best option.

“End-stage” doesn’t mean “surgery now.”


The term describes how advanced the arthritis looks — bone-on-bone — not a deadline. Some patients with end-stage arthritis continue to manage well with bracing, injections, medication, and activity changes.

FAQ


Chapter 2

Ankle Arthrodesis vs. Total Ankle Replacement

By Dr. Sagar Desai, MD, MSc, FRCSC
Orthopaedic Surgeon, Foot and Ankle Reconstruction
Toronto, Ontario, Canada

When surgery is required for end-stage ankle arthritis, there are two primary options: an ankle fusion (arthrodesis) or a total ankle replacement (arthroplasty). Both are designed to relieve pain, but they achieve it in very different ways.

An ankle fusion permanently joins the tibia to the talus so the joint no longer moves. Its major advantages are excellent pain relief and durability; the trade-off is stiffness while walking, and over many years the surrounding joints of the foot may develop arthritis as they compensate for lost ankle motion. It remains an excellent option for many patients.

Advances in modern orthopaedic surgery have made total ankle replacement an excellent option for many patients too. It removes the damaged arthritic surfaces and replaces them with metal and polyethylene components — preserving much of the ankle’s motion while relieving pain, which often allows a more natural walking pattern and an active lifestyle without the stiffness of a fusion.

Option 1

Ankle Fusion (Arthrodesis)

Ankle motion - Eliminated

Pain relief - Excellent

Durability - Often lifelong

Long-term trade-off - Adjacent-joint arthritis

Option 2

Total Ankle Replacement

Ankle motion - Preserved

Pain relief - Excellent

Walking pattern - More natural

Long-term trade-off - Possible revision

Neither procedure is universally better. Large trials and long-term studies show similar overall function, with fusion tending to require fewer reoperations and replacement preserving motion and sometimes modestly improving walking function. Dr. Desai has performed fusions successfully for 10 years, but increasingly favours replacement for appropriately selected patients.

Good candidate for replacement

Significant arthritic pain, reasonable bone quality, good ankle alignment, and realistic expectations for recovery. Overall health, activity level, and the surrounding joints matter more than age alone.

Consider fusion instead

Very high physical demands, significant deformity, poor bone quality, or medical conditions that make a replacement less predictable.

Clinical Literature & Key Studies

  • 1. Glazebrook M, Balasubramaniam U, Walls A, et al. Outcomes of Total Ankle Replacement Versus Ankle Arthrodesis for the Treatment of End-Stage Ankle Arthritis: A Concise Follow-Up, at a Minimum of 10 Years, of a Previous Report. J Bone Joint Surg Am. 2025.

    Longest comparative follow-up (minimum 10 years, mean 13.2) from the COFAS database. Long-term function was similar; arthrodesis patients were more likely to need no further surgery (70% vs. 58%), while TAR patients kept ankle motion but had a higher reoperation rate.

  • 2. Goldberg AJ, Chowdhury K, Bordea E, et al. Total Ankle Replacement Versus Ankle Arthrodesis for Patients Aged 50–85 Years With End-Stage Ankle Osteoarthritis: The TARVA RCT. Health Technol Assess. 2023.

    RCT of 303 patients across 17 UK hospitals. No significant overall difference in the primary outcome; post hoc analysis favoured fixed-bearing TAR over fusion, and TAR appeared cost-effective.

  • 3. Sangeorzan BJ, Ledoux WR, Shofer JB, et al. Comparing 4-Year Changes in Patient-Reported Outcomes Following Ankle Arthroplasty and Arthrodesis. J Bone Joint Surg Am. 2021.

    414 TAA vs. 103 AA patients at 48 months. Both improved significantly, with a modest but statistically significant advantage for TAA in patient-reported function (FAAM ADL +9, SF-36 PCS +3.5).

  • 4. Liu S, Wang Y, Zhang M, et al. A Comparative Study of Modern Total Ankle Replacement and Ankle Arthrodesis for Ankle Osteoarthritis at Different Follow-Up Times: A Systematic Review and Meta-Analysis. Int Orthop. 2023.

    Meta-analysis of 37 studies. TAR showed better PROMs and fewer complications short-term; long-term, arthrodesis had lower complication and revision rates with similar clinical scores — the best choice may depend on time horizon and expectations.

FAQ


Chapter 3

Total Ankle Replacement

By Dr. Sagar Desai, MD, MSc, FRCSC
Orthopaedic Surgeon, Foot and Ankle Reconstruction
Toronto, Ontario, Canada

Dr. Desai performs total ankle replacement using the Stryker PROPHECY® Infinity™ Total Ankle System, one of the most advanced patient-specific systems available. Unlike traditional joint replacement, the work begins well before the operation: about three months ahead, a specialized CT scan of the ankle and lower leg creates a detailed 3D model of the patient’s anatomy. Engineers use it to build custom cutting guides designed exclusively for that ankle — a process that takes roughly six weeks — so the operation is tailored to each patient’s unique anatomy.

On the day of surgery, the anesthesiologist places a specialized nerve block behind the knee, numbing the lower leg and providing pain relief that lasts about three days, with the anesthesia team checking in daily to guide the transition to oral medication. Many patients choose light sedation and sleep through the procedure; others prefer to stay awake. Through an incision over the front of the ankle, the custom PROPHECY guides are used to remove the damaged surfaces of the tibia and talus and replace them with engineered metal and polyethylene components. For significant deformity, bone loss, or more complex arthritis, Dr. Desai may use the Infinity INBONE™ system instead, which adds a stem within the tibia for extra support and stability.

45–60 min

Typical straightforward replacement (complex cases up to 2 hrs)

Day surgery

No overnight hospital stay

∽3 days

Pain relief from the nerve block behind the knee

Longevity

Modern ankle replacements have demonstrated excellent durability — roughly 90–95% are still functioning well 10–12 years after surgery, and many last considerably longer. If an implant eventually wears out, revision replacement is often possible, though it’s more complex than the original operation. Some of the studies below use other implants (such as Salto Talaris and Hintegra), but Dr. Desai considers the results relevant regardless of implant.

Outcomes & Risks

∽85%

Of patients satisfied with the outcome

∽10%

Find no particular benefit

∽5%

Report their condition has worsened, usually due to a recognized complication

Like any operation, total ankle replacement carries potential risks:

  • Serious infection: 1

  • Nerve injury / numbness (permanent in rare cases; CRPS rare): Common, usually temporary

  • Implants healing (incorporating) into bone properly: 90% of the time

  • Blood clots (DVT / PE): Uncommon

  • Vascular injury (higher risk with diabetes or blood-vessel disease): Potential

  • Regional anesthesia complications: <1%

Disclosure. Dr. Desai recommends perioperative immunonutrition (an amino acid and omega-3 combination) to support surgical recovery. He discloses that this is his own company’s product — a conflict of interest patients should be aware of when discussing it.

Clinical Literature & Key Studies

  • 1. Richter D, Krähenbühl N, Susdorf R, et al. What Are the Indications for Implant Revision in Three-Component Total Ankle Arthroplasty? Clin Orthop Relat Res. 2021.

    1,006 three-component TAAs, mean 8.8-year follow-up. Cumulative revision incidence of 4.8% at 5 years and 12.1% at 10 years; instability (34%) and aseptic loosening (28%) were the most common reasons.

  • 2. Sadoun M, Gaudot F, Bauer T, Stiglitz Y. SALTO TALARIS Total Ankle Arthroplasty at a Minimum of 10 Years of Follow-Up: Survival and Radiographic and Clinical Outcomes in a Series of 144 Ankles. J Bone Joint Surg Am. 2026.

    Mean 12-year follow-up. 96.2% implant survival at 10 years (99% with conversion to arthrodesis as the endpoint), median AOFAS of 98, and 43% of patients describing a ‘forgotten joint.’

  • 3. McReavy BR, Stone McGaver R, Fritz JE, et al. 1121 Salto Talaris Total Ankle Arthroplasties by a Single Surgeon: Midterm Survivorship, Complications, and Patient-Reported Outcomes. Foot Ankle Int. 2026.

    Largest single-surgeon cohort, mean 5.5-year follow-up. 94.6% survivorship, 5.4% failure and 12.0% reoperation rates; aseptic loosening and deep infection were the leading causes of failure.

  • 4. Dahill M, Kostusiak M, Dean M, et al. Midterm Survivorship of 106 Infinity Total Ankle Replacements: A Case Series From 2 Non-Designer UK Centers. Foot Ankle Int. 2025.

    Mean 98-month follow-up. Survivorship of 91.1% at 8 years; unexplained pain was the most common reason for revision (5 of 8).

  • 5. Shaffrey I, O’Malley E, Henry JK, et al. Midterm Clinical Outcomes, Radiographic Outcomes, and Survivorship of the Infinity Total Ankle Arthroplasty. Foot Ankle Int. 2023.

    65 Infinity TAAs, mean 6.5-year follow-up. 93.8% survivorship, substantial and stable FAOS improvement, and stable radiographic outcomes.

  • 6. Clough TM, Bitar S. Clinical Comparison of Mobile-Bearing Versus Fixed-Bearing Total Ankle Arthroplasty: Case Series of 236 Ankles From a Non-Designer Centre. Bone Joint J. 2026.

    118 Zenith (mobile-bearing) vs. 118 Infinity (fixed-bearing). Five-year survival of 98.7% for Infinity vs. 91.3% for Zenith, with both groups improving significantly.

  • 7. Townshend DN, Bing AJF, Clough TM, Sharpe IT, Goldberg A. Early Experience and Patient-Reported Outcomes of 503 INFINITY Total Ankle Arthroplasties. Bone Joint J. 2021.

    503 Infinity TAAs across 11 centers, mean 16.2-month follow-up. 1.0% early revision rate, 8.8% overall complication rate, and significant improvement across all functional scores.

FAQ


Chapter 4

Total Ankle Replacement Recovery

By Dr. Sagar Desai, MD, MSc, FRCSC
Orthopaedic Surgeon, Foot and Ankle Reconstruction
Toronto, Ontario, Canada

Recovery is a gradual process. Many patients notice a big improvement in pain within the first few weeks, but the implant, surrounding bone, muscles, tendons, and soft tissues all need time to heal — and gains in strength, mobility, and endurance often continue for up to a year. One of the biggest advantages of Dr. Desai’s protocol is that walking is allowed immediately in a walking boot, which helps maintain strength, reduce stiffness, and keep patients independent. That doesn’t mean long distances: the early goal is simply normal daily activity around the home.

The first 72 hours are about letting the body begin healing. The nerve block typically lasts two to three days, and prescribed pain medication should be started before it fully wears off. The leg should be elevated above heart level as much as possible, the boot stays on at all times, and the dressing stays clean and dry until the first post-operative visit. Through the first two weeks, pain usually improves quickly — many patients need only occasional Tylenol or an anti-inflammatory after the first several days — but feeling better isn’t the same as being healed. Light upper-body and seated exercise is fine, but avoid sweating, since the ankle sweats too.

At the two-week visit, stitches come out and normal showering can resume once the incision has healed (baths, pools, lakes, and hot tubs wait until it has fully healed). The boot is worn about 23 hours a day, weight-bearing progresses, and formal physiotherapy begins. Swelling often increases at this stage as activity increases — that’s normal. Around six weeks, patients wean out of the boot into supportive athletic shoes over one to two weeks, and rehab shifts toward strength, balance, endurance, and confidence.

Don’t mistake feeling better for being healed.

Long walks, shopping trips, prolonged standing, and household projects in the first few weeks are the most common causes of unnecessary swelling and a slower recovery. If the ankle gets more swollen or sore, ease off for a day or two before progressing again.

By three months, most patients are in regular shoes and walking comfortably, and recovery shifts from healing to optimizing function. Walking, cycling, swimming, golf, hiking, and travel are all encouraged. Most patients say that somewhere between six months and a year, they stop thinking about their ankle replacement in everyday life — exactly the outcome the whole process is working toward.

Day 0–3

Walking boot, weight-bearing allowed, nerve block, elevation

Weeks 0–2

Protected healing — normal activity at home only, knee scooter

Weeks 2–6

Stitches out, physiotherapy begins, stationary bike in the boot

3–12 Months

Regular shoes, low-impact activity, ongoing gains in strength

Weeks 6–12

Wean out of boot, compression socks, travel, golf ~10–12 wks

What You’ll Work On in Physiotherapy

Weeks 2–6

Motion & early strength

Weight-bearing: As tolerated in boot

Range of motion: Passive & active

Stretching: Ankle, subtalar joint & midfoot (dorsiflexion focus); weight-bearing stretches

Strength: Knee & hip; isometric ankle; resistance bands; double-leg heel raises

Balance: Proprioception, wobble board, tandem stance toward single-leg

Walking Gait retraining

At home Structured home exercise program

Beyond 6 weeks

Strength, balance & confidence

Footwear: Wean out of boot over 1–2 wks

Strength: Single-leg heel raises; resistance bands & ankle weights

Flexibility: Foam rolling & flexibility exercises

Balance: BOSU & unstable surfaces; dynamic single-leg

Function: Work-specific rehab when appropriate

At home: Ongoing home exercise program

Devices Used During Recovery

Walking boot

Applied in the OR; worn ~23 hrs/day, including sleep, for the first ~6 weeks.

Knee scooter

Dr. Desai believes it’s the most effective method after surgery — used for the first 2–3 weeks.

Compression stocking

20–30 mmHg recommended for the first year to minimize swelling; Dr. Desai highly recommends starting around 6 weeks.

Stationary bike

From ~2 weeks, in the boot until the 6-week mark.

Permanently avoid repetitive high impact.

To maximize implant longevity, Dr. Desai recommends permanently avoiding running, jumping, hopping, basketball, and similar sports. Low-impact activities like cycling, swimming, golf, and hiking are encouraged.

FAQ